Functional study of the novel multidrug resistance gene HA117 and its comparison to multidrug resistance gene 1
نویسندگان
چکیده
منابع مشابه
Functional study of the novel multidrug resistance gene HA117 and its comparison to multidrug resistance gene 1
BACKGROUND The novel gene HA117 is a multidrug resistance (MDR) gene expressed by all-trans retinoic acid-resistant HL-60 cells. In the present study, we compared the multidrug resistance of the HA117 with that of the classical multidrug resistance gene 1 (MDR1) in breast cancer cell line 4T1. METHODS Transduction of the breast cancer cell line 4T1 with adenoviral vectors encoding the HA117 g...
متن کاملResearchFunctional study of the novel multidrug resistance gene HA 117 and its comparison to multidrug resistance gene 1
Background: The novel gene HA117 is a multidrug resistance (MDR) gene expressed by all-trans retinoic acid-resistant HL-60 cells. In the present study, we compared the multidrug resistance of the HA117 with that of the classical multidrug resistance gene 1 (MDR1) in breast cancer cell line 4T1. Methods: Transduction of the breast cancer cell line 4T1 with adenoviral vectors encoding the HA117 g...
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background: for the first time we tested an association between the human multidrug resistance gene 1 (mdr1) polymorphisms (snps) and idiopathic pulmonary fibrosis (ipf). several mdr1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. materials and methods: we genotyped three mdr1 polymorphisms of 48 ipf patients and 100 control subj...
متن کاملHA117 gene increased the multidrug resistance of K562 cells in vitro: an investigation to the function of a novel gene related to drug resistance
OBJECTIVE A novel multi-drug resistance gene named as HA117 has been screened and cloned in multidrug resisitant leukemia cell lines in our previous research, but its function is still unknown. In this study, HA117 gene was investigated whether it could increase the drug resistance in chronic myelogenous myeloid leukemia cell line K562. METHODS HA117 was cloned and adenovirus vectors were con...
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Irreversible growth arrest (also called senescence) has emerged recently as a tumor suppressor mechanism and a key determinant of cancer chemotherapy outcome. Previous work from our laboratory suggested that the cellular ability to undergo or to escape senescence dictates its fate to become drug-sensitive or drug-resistant, respectively. In the present study, we made the hypothesis that longevi...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2010
ISSN: 1756-9966
DOI: 10.1186/1756-9966-29-98